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LFA-1a (ITGAL)/CD11a
英文名：LFA-1a (ITGAL)/CD11a
Cas号：
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114491-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, CD11a antigen |
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| 产品参数 | 【产品介绍】In the immune system, integrins have
essential roles in leukocyte trafficking a n d function. These include immune cell attachment to endothelial a n d antigen-presenting cells, cytotoxicity, a n d extravasation into tissues (1). Integrin adhesion recept o r s transduce signals that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation a n d survival. Their intracellular domain has no catalytic function, indicating that interaction with other transducing molecules is crucial f o r integrin- mediated signaling. JAB1 (Jun activation domain- binding protein 1), a coactivat o r of the c-Jun transcription fact o r , has been identified as a protein that interacts with the cytoplasmic domain of the beta2 subunit of the alphaL/beta2 integrin LFA-1 (2). Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer f o r mation a n d n o r mal cell surface expression of these recept o r s, leading to life-threatening bacterial infections (3) WB: 1:20,000 IHC: 1:100 250 ICC: 1:100 250 Flow Cytometry: 1:80 IP: 1:100 A. Western blot analysis on Jurkat cell lysate using anti-LFA-1a RabMAb (cat. # 1904-1), dilution 1:20,000. B. Immunohistochemical staining of paraffin-embedded human spleen using anti-LFA-1a RabMAb (cat. #1904-1). |
| 性状 | 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human 【克隆 ID】EP1285Y 【用途】WB , IHC , ICC , FC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】180 kDa |
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