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LFA-β2 (ITGB2) Phospho (pS745)

英文名：LFA-β2 (ITGB2) Phospho (pS745)
Cas号：
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别 名 Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta, Complement recept o r C3 subunit beta, CD18 antigen
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】In the immune system, integrins have
essential roles in leukocyte trafficking a n d
function. These include immune cell attachment
to endothelial a n d antigen-presenting cells,
cytotoxicity, a n d extravasation into tissues (1).
Integrin adhesion recept o r s transduce signals
that control complex cell functions which require
the regulation of gene expression, such as
proliferation, differentiation a n d survival.
Their intracellular domain has no catalytic
function, indicating that interaction with other
transducing molecules is crucial f o r integrin-
mediated signaling. JAB1 (Jun activation domain-
binding protein 1), a coactivat o r of the
c-Jun transcription fact o r , has been identified as
a protein that interacts with the cytoplasmic domain of
the beta2 subunit of the alphaL/beta2 integrin LFA-1
(2). Patients with leukocyte adhesion molecule
(CD11/CD18, beta 2 integrins) deficiency have
structural defects in the common beta subunit (CD18),
which prevent heterodimer f o r mation a n d n o r mal
cell surface expression of these recept o r s, leading
to life-threatening bacterial infections (3)

WB: 1:500
IHC: 1:250 500
ICC: 1:250 500
IP: 1:100

A. Western blot analysis on Jurkat cell lysates
using anti-Phospho-LFA-β2 (pS745) RabMAb
(cat. #1911-1), 1:500 dilution. Cells were either
(A) untreated (B) treated with AP.

B. Immunohistochemical analysis of human tonsils
using anti-Phospho- LFA-β2 (pS745) RabMAb (cat. # 1911-1).
性状 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human , Mouse , Rat
【克隆 ID】EP1288Y
【用途】WB , IHC , ICC , IP
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】85 kDa
贮存
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