LIN28A DyLight® 594

英文名:LIN28A DyLight® 594
Cas号:
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别 名 LIN28A antibody, CSDD1 antibody, FLJ12457 antibody, LIN-28 antibody, LIN28 antibody, ZCCHC1 antibody, Protein lin-28 homolog A antibody, Zinc finger CCHC domain-containing protein 1 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】LIN28A, a promoter of pluripotency, is
a developmentally regulated RNA binding protein,
which selectively blocks the processing of pri-let-7
miRNAs in embryonic cells (1,2). One of the let-7
family members, let-7g targets and represses LIN28
through four 3'-UTR binding sites. It has been reported
that LIN28/let-7 pair has the potential to act as
a 'toggle switch' that balances the decision to
maintain pluripotency vs. differentiation (3). LIN28
was identified as a negative regulator of miRNA
biogenesis and suggested that it may play a central role
in blocking miRNA-mediated differentiation in stem cells
and in certain cancers (1).

Recommended Applications
ICC
Applications and Recommended Dilution Factors
ICC: 1:50 - 100
Species Reactivity
Human

Products Data

Immunofluorescent analysis of NCCIT cells using
LIN28A RabMAb (DyLight 594 conjugate, cat.# 4585-1)
(red) and Dapi (blue).

Specificity
A synthetic peptide corresponding to residues in
human LIN28A was used as an immunogen.
性状 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human
【克隆 ID】EPR4640
【用途】ICC
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】26kDa
贮存 Store at 2-8° C. PBS (pH 7.2), 0.02% sodium azide, 0.05% BSA. Protect from light. Stable for 6 months from date of receipt.
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