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Recombinant Human Fibroblast Growth Factor 21
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| 性状 | Recombinant Human Fibroblast Growth Factor 21 是一个非典型的成纤维细胞生长因子 (FGF)，作为代谢调节剂，具有多重效应。
Synonyms rHuFGF-21; Fibroblast Growth Factor-21(FGF-21) ; 重组人成纤维细胞生长因子 21 Species Human Source E. coli Accession Q9NSA1 Gene ID 26291 Molecular Weight Approximately 19.4 kDa AA Sequence HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA S Biological Activity The ED50 is <0.5 μg/mL as measured by FGF-receptors transfected BaF3 cells, corresponding to a specific activity of > 2.0 × 103 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Fibroblast Growth Factor 21 (rHuFGF-21) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1 % BSA. Storage & Stability Lyophilized recombinant Human Fibroblast Growth Factor 21 (rHuFGF-21) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Human Fibroblast Growth Factor 21 (FGF21) acts in an endocrine mannerand and is a metabolic regulator with pleiotropic effects. FGF21 possesses protective effects in the cardiovascular system, primarily due to metabolic effects other thanmaintaining energy homoeostasis. FGF21 is also involved inseveral processes, including reducing arteriosclerotic plaque formation in major vessels and protecting themyocardium from injuries caused by infarction, ischaemia-reperfusion, isoproterenol-induced hypertrophy anddiabetic lipotoxicity. In addition, FG2F1 induces these effects by atten-uating remodelling-related inflammation and oxidativestress and promoting myocardial energy metabolism, as well as by preventing lipid- or diabetes-induced cardiaccell apoptosis. FGF21 functions via its interaction with FGF receptors (FGFRs), with the assistance of the co-receptor β-Klotho. Structurally, the FGFRs are divided into four isoforms, FGFR1-FGFR4[1]. |
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- Recombinant Human Endostatin (P.pastoris-expressed)
- Recombinant Human Epigen
- Recombinant Human Epigen (CHO-expressed)
- Recombinant Human Epiregulin
- Recombinant Human Fibroblast Growth Factor 21
- Recombinant Human Fibroblast Growth Factor 23
- Recombinant Human Fibroblast Growth Factor 4
- Recombinant Human Granulocyte Colony Stimulating Factor
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