Recombinant Human Fibroblast Growth Factor 21

英文名:
Cas号:
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货号 规格 货期 库存 价格 会员价 订购
1308132514-10 μg 0 ¥2800 请登录
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1308132514-50 μg 0 ¥7200 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Fibroblast Growth Factor 21 是一个非典型的成纤维细胞生长因子 (FGF),作为代谢调节剂,具有多重效应。
Synonyms
rHuFGF-21; Fibroblast Growth Factor-21(FGF-21) ; 重组人成纤维细胞生长因子 21
Species
Human

Source
E. coli

Accession
Q9NSA1

Gene ID
26291

Molecular Weight
Approximately 19.4 kDa

AA Sequence
HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA S

Biological Activity
The ED50 is <0.5 μg/mL as measured by FGF-receptors transfected BaF3 cells, corresponding to a specific activity of > 2.0 × 103 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Fibroblast Growth Factor 21 (rHuFGF-21) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1 % BSA.

Storage & Stability
Lyophilized recombinant Human Fibroblast Growth Factor 21 (rHuFGF-21) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Human Fibroblast Growth Factor 21 (FGF21) acts in an endocrine mannerand and is a metabolic regulator with pleiotropic effects. FGF21 possesses protective effects in the cardiovascular system, primarily due to metabolic effects other thanmaintaining energy homoeostasis. FGF21 is also involved inseveral processes, including reducing arteriosclerotic plaque formation in major vessels and protecting themyocardium from injuries caused by infarction, ischaemia-reperfusion, isoproterenol-induced hypertrophy anddiabetic lipotoxicity. In addition, FG2F1 induces these effects by atten-uating remodelling-related inflammation and oxidativestress and promoting myocardial energy metabolism, as well as by preventing lipid- or diabetes-induced cardiaccell apoptosis. FGF21 functions via its interaction with FGF receptors (FGFRs), with the assistance of the co-receptor β-Klotho. Structurally, the FGFRs are divided into four isoforms, FGFR1-FGFR4[1].
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