Recombinant Human Fibroblast Growth Factor 23

英文名:
Cas号:
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Fibroblast Growth Factor 23 是一种独特的成纤维细胞生长因子 (FGF),它是一种激素,通过辅因子如 α-Klotho 与 FGF 受体结合发挥作用,在软骨形成过程中诱导肥大和矿化的产生。
Synonyms
rHuFGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor ; 重组人成纤维细胞生长因子 23
Species
Human

Source
E. coli

Accession
Q9GZV9

Gene ID
8074

Molecular Weight
Approximately 25.3 kDa

AA Sequence
YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI

Biological Activity
The ED50 is <0.5 μg/mL as measured by FGF-receptors transfected BaF3 cells, corresponding to a specific activity of >2.0 × 103 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Fibroblast Growth Factor 23 (rHuFGF-23) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1 % BSA.

Storage & Stability
Lyophilized recombinant Human Fibroblast Growth Factor 23 (rHuFGF-23) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Recombinant Human Fibroblast Growth Factor 23 is a unique FGF subfamily member, acts as a a hormone and requires a cofactor to signal through canonical FGFR, and induces hypertrophy and mineralization during chondrogenesis[1]. FGF23 is a secreted, circulating protein of 32 kDa that is predominantly produced by osteocytesin bone and functions in distant target organs in an endocrine fashion. FGF23 generally requires an FGF receptor (FGFR) and α-Klotho to evoke its signaling. GF23 binds to an FGFR-α-Klotho complex and induces the phosphorylation of FGFR and the expression of early growth response-1 (Egr-1), which encodes a transcription factor[2].
贮存
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