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Recombinant Human Fibroblast Growth Factor 23
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| 性状 | Recombinant Human Fibroblast Growth Factor 23 是一种独特的成纤维细胞生长因子 (FGF)，它是一种激素，通过辅因子如 α-Klotho 与 FGF 受体结合发挥作用，在软骨形成过程中诱导肥大和矿化的产生。
Synonyms rHuFGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor ; 重组人成纤维细胞生长因子 23 Species Human Source E. coli Accession Q9GZV9 Gene ID 8074 Molecular Weight Approximately 25.3 kDa AA Sequence YPNASPLLGS SWGGLIHLYT ATARNSYHLQ IHKNGHVDGA PHQTIYSALM IRSEDAGFVV ITGVMSRRYL CMDFRGNIFG SHYFDPENCR FQHQTLENGY DVYHSPQYHF LVSLGRAKRA FLPGMNPPPY SQFLSRRNEI PLIHFNTPIP RRHTRSAEDD SERDPLNVLK PRARMTPAPA SCSQELPSAE DNSPMASDPL GVVRGGRVNT HAGGTGPEGC RPFAKFI Biological Activity The ED50 is <0.5 μg/mL as measured by FGF-receptors transfected BaF3 cells, corresponding to a specific activity of >2.0 × 103 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Fibroblast Growth Factor 23 (rHuFGF-23) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1 % BSA. Storage & Stability Lyophilized recombinant Human Fibroblast Growth Factor 23 (rHuFGF-23) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Recombinant Human Fibroblast Growth Factor 23 is a unique FGF subfamily member, acts as a a hormone and requires a cofactor to signal through canonical FGFR, and induces hypertrophy and mineralization during chondrogenesis[1]. FGF23 is a secreted, circulating protein of 32 kDa that is predominantly produced by osteocytesin bone and functions in distant target organs in an endocrine fashion. FGF23 generally requires an FGF receptor (FGFR) and α-Klotho to evoke its signaling. GF23 binds to an FGFR-α-Klotho complex and induces the phosphorylation of FGFR and the expression of early growth response-1 (Egr-1), which encodes a transcription factor[2]. |
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- Recombinant Human Epigen
- Recombinant Human Epigen (CHO-expressed)
- Recombinant Human Epiregulin
- Recombinant Human Fibroblast Growth Factor 21
- Recombinant Human Fibroblast Growth Factor 23
- Recombinant Human Fibroblast Growth Factor 4
- Recombinant Human Granulocyte Colony Stimulating Factor
- Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor(CHO-expressed)
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