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Recombinant Human Interleukin-21
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| 性状 | Recombinant Human Interleukin-21 是 1 类细胞因子，由体内活化的 CD4+ T 细胞产生。刺激 T 细胞，B 细胞和 NK 细胞增殖与分化 。
Synonyms rHuIL-21; Za11; IL21 Species Human Source E. coli Accession Q9HBE4 Gene ID 59067 Molecular Weight Approximately 15.4 kDa AA Sequence MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS Biological Activity The ED50 is <0.5 ng/mL as measured by Mino cells, corresponding to a specific activity of >2.0 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-21 (rHuIL-21) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Human Interleukin-21 (rHuIL-21) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Interleukin-21 (IL-21) is a pleiotropic cytokine that has key functions in both the innate and adaptive immunity and the regulation of autoimmunity. IL-21 has a range of activities likely to potentiate antitumor immunoresponses. IL-21 has a role as a single agent in the treatment of melanoma. IL-21 also has significant activity against various types of cancer in combination with monoclonal antibodies or signaling inhibitors[1]. Recombinant human interleukin-21 (rIL-21), a human recombinant interleukin, with Cetuximab, a monoclonal antibody, targeting the epidermal growth factor receptor[2]. |
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