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Recombinant Human Parathyroid Hormone, 1-84a.a.
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| 性状 | Recombinant Human Parathyroid Hormone, 1-84a.a.是矿物离子代谢的主要调节剂。
Synonyms rHuPTH; Parathormone; Parathyrin Species Human Source E. coli Accession P01270 Gene ID 5741 Molecular Weight Approximately 9,000 Da AA Sequence SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ Biological Activity The ED50 is <0.1 μg/mL as measured by UMR106 cell/cAMP method, corresponding to a specific activity of >1.0 × 104 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 1.15 mg sodium citrate, sodium chloride 7.31 mg, 0.21 mg citric acid, 0.1117 mg EDTA-Na2, 0.2 mg Tween 80 and 50 mg Mannitol. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Parathyroid Hormone, 1-84a.a. (rHuPTH (1-84a.a.)) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Parathyroid Hormone, 1-84a.a. (rHuPTH (1-84a.a.)) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Recombinant Human Parathyroid Hormone, 1-84a.a. is a full-length replica of the endogenous Parathyroid hormone molecule, which consists of an amino (N)-terminal structure (first 34 amino acids) and a carboxyl (C)-terminal structure (last 50 amino acids). Full-length recombinant human parathyroid hormone [rhPTH (1-84); Natpara] is approved in the USA as an adjunct to calcium and vitamin D therapy for control of hypocalcaemia in patients with hypoparathyroidism. Parathyroid Hormone regulates calcium and phosphorus levels by acting on the bone, kidneys and intestines. In the bone, Parathyroid hormone mobilizes calcium and phosphorus into the circulation by stimulating bone resorption. Parathyroid hormone stimulates osteoblasts to increase the expression of receptor activator of nuclear factor j-B ligand (RANKL)[1]. |
| 贮存 |
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- Recombinant Human Parathyroid Hormone, 1-84a.a.
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