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Recombinant Mouse Betacellulin (HEK293-expressed)
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| 性状 | Recombinant Mouse Betacellulin (HEK293-expressed) 是表皮生长因子家族的一员，可诱导胰腺β 细胞的分化，促进β 细胞的再生。
Synonyms rMuBetacellulin; BTC; Probetacellulin ; 重组小鼠 Betacellulin (HEK293细胞表达) Species Mouse Source HEK 293 Accession Q05928 Gene ID 12223 Molecular Weight 19-24 kDa AA Sequence DGNTTRTPET NGSLCGAPGE NCTGTTPRQK VKTHFSRCPK QYKHYCIHGR CRFVVDEQTP SCICEKGYFG ARCERVDLFY Biological Activity The ED50 is <0.08 ng/mL as measured by 3T3 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Mouse Betacellulin (HEK293-expressed) (rMuBetacellulin) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Mouse Betacellulin (HEK293-expressed) (rMuBetacellulin) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, induces differentiation of pancreatic β-cells and promotes regeneration of β-cells in experimental diabetes. BTC stimulates DNA synthesis in fibroblasts and vascular smooth muscle cells. BTC plays a role in regulating growth and/or differentiation of endocrine precursor cells of the fetal pancreas. BTC is found to convert amylase-secreting pancreatic AR42J cells into insulin-producing cells and to have a mitogenic effect in human undifferentiated pancreatic epithelial cells[1]. |
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