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Recombinant Rat Beta Defensin-4
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| 性状 | Recombinant Rat Beta Defensin-4 是一种具有广谱抗菌活性的诱导肽。
Synonyms rRtBD-4; DEFB-4; Beta-defensin 104; DEFB4; DEFB104 ; 重组大鼠 β-防御素-4 Species Rat Source E. coli Accession O88514 Gene ID 64389 Molecular Weight Approximately 4.4 kDa AA Sequence QSINNPITCL TKGGVCWGPC TGGFRQIGTC GLPRVRCCKK K Biological Activity Full biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 0.1-100.0 ng/ml. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 10 mM PB, pH 7.4, 500 mM NaCl. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Rat Beta Defensin-4 (rRtBD-4) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability Lyophilized recombinant Rat Beta Defensin-4 (rRtBD-4) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Recombinant Rat Beta Defensin-4 is an inducible peptide with a broad spectrum antimicrobial activity. Human Beta Defensin-4 (hBD-4) expression is up-regulated by infection with gram-positive and gram-negative bacteria in human respiratory epithelial cells, and in response to phorbol 12-myristate 13-acetate, but not in response to other inflammatory factors that up-regulate the expression of hBD-2 or hBD-3[1]. |
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