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Recombinant Human Beta Defensin-4
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| 性状 | combinant Human Beta Defensin-4 是一种具有特异性盐敏谱的、抗菌活性诱导肽。
Synonyms rHuBD-4; DEFB-4; Beta-defensin 104; DEFB4; DEFB104 ; 重组人 β-防御素-4 Species Human Source E. coli Accession Q8WTQ1 Gene ID 140596 Molecular Weight Approximately 6.0 kDa AA Sequence EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP Biological Activity Full biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 0.1-100 ng/mL. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 20 mM PBS, pH 7.4, 130 mM NaCl. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Beta Defensin-4 (rHuBD-4) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability Lyophilized recombinant Human Beta Defensin-4 (rHuBD-4) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Human Beta Defensin-4 (hBD-4) expression is up-regulated by infection with gram-positive and gram-negative bacteria in human respiratory epithelial cells, and in response to phorbol 12-myristate 13-acetate, but not in response to other inflammatory factors that up-regulate the expression of hBD-2 or hBD-3. Synthetic hBD-4 exhibits a selective, salt-sensitive spectrum of antimicrobial activity, and it represents one of the most active antimicrobial peptides against Pseudomonas aeruginosa (minimal inhibitory concentration: 4.1 μg/mL) known to date[1]. |
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