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Recombinant Human Dickkopf Related Protein-1 (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132672-10 μg 0 ￥5800 请登录
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1308132672-50 μg 0 ￥17800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Dickkopf Related Protein-1 (HEK293-expressed) 可通过抑制 Wnt 信号通路来参与胚胎发育过程。
Synonyms
rHuDKK-1; hDkk-1; SK ; 重组人Dickkopf 相关蛋白-1 (DKK1) (hek293表达)
Species
Human

Source
HEK 293

Accession
O94907

Gene ID
22943

Molecular Weight
38-40 kDa

AA Sequence
TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYPGG NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRHHHHHH H

Biological Activity
The ED50 is <4 μg/mL as measured in stimulation of alkaline phosphatase activity using CCl-226 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Dickkopf Related Protein-1 (HEK293-expressed) (rHuDKK-1) to 100 μg/mL using ddH2O or PBS.

Storage & Stability
Lyophilized recombinant Human Dickkopf Related Protein-1 (HEK293-expressed) (rHuDKK-1) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Human Dickkopf Related Protein-1 a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the Wnt signaling pathway. Dickkopf WNT signaling pathway inhibitor 1 (Dkk1) is a protein-coding gene that acts from the anterior visceral endoderm[1][2]. DKK1 is demonstrated to antagonize the Wnt/β-catenin pathway via a reduction in β-catenin and an increase in OCT4 expression[3].
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