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Recombinant Rat Eotaxin-2/CCL24

英文名：
Cas号：
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货号 规格 货期 库存 价格 会员价 订购
1308132678-10 μg 0 ￥3200 请登录
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1308132678-50 μg 0 ￥8400 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Rat Eotaxin-2/CCL24 对静息T淋巴细胞和嗜酸性粒细胞具有趋化作用。
Synonyms
rRtEotaxin-2/CCL24; C-C motif chemokine 24; CK-beta-6; MPIF-2; MPIF2; SCYA24 ; 重组小鼠嗜酸性细胞趋化因子 (CCL24)
Species
Rat

Source
E. coli

Accession
Q5PPP2

Gene ID
288593

Molecular Weight
Approximately 10.5 kDa

AA Sequence
MPTGSVTIPS SCCVTFISKK IPVNRVISYQ LANGSICPKA GVIFITKKGH KICTDPKLPW VQKHIKNLDA KRNQPSEGAK ALGPKFVIQK LRGNSTKV

Biological Activity
Full biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration of 50-250 ng/ml.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 2× PBS, pH 7.4.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Rat Eotaxin-2/CCL24 (rRtEotaxin-2/CCL24) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA.

Storage & Stability
Lyophilized recombinant Rat Eotaxin-2/CCL24 (rRtEotaxin-2/CCL24) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Rat CCL24 is a chemokine containing four conserved cysteine residues, two of which are adjacent. It is expressed by activated monocytes and activated T lymphocytes. CCL24 is expressed in jejunum and spleen constitutively and is upregulated by allergen challenge and IL4 overexpression. CCL24 mainly mediates atopic disorders, parasitic infections and systemic diseases via binding to its only receptor CCR3. Human CCL24 increases the proliferation and apoptosis of DSCs, whereas on the whole it promotes the number of DSCs. CCL24 is a beneficial factor for the process of decidualization in human early pregnancy[1].
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