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Recombinant Mouse Fibroblast Growth Factor-21
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| 性状 | Recombinant Mouse Fibroblast Growth Factor-21 是一种可参与调节糖、脂、胆汁酸和磷酸盐代谢的代谢激素。
Synonyms rMuFGF-21; FGF21 ; 重组小鼠成纤维细胞生长因子-21 Species Mouse Source E. coli Accession Q9JJN1 Gene ID 56636 Molecular Weight Approximately 19.9 kDa AA Sequence AYPIPDSSPL LQFGGQVRQR YLYTDDDQDT EAHLEIREDG TVVGAAHRSP ESLLELKALK PGVIQILGVK ASRFLCQQPD GALYGSPHFD PEACSFRELL LEDGYNVYQS EAHGLPLRLP QKDSPNQDAT SWGPVRFLPM PGLLHEPQDQ AGFLPPEPPD VGSSDPLSMV EPLQGRSPSY AS Biological Activity The ED50 is <0.5 μg/mL as measured by FGF-receptors transfected BaF3 cells, corresponding to a specific activity of >2.0 × 103 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 3× PBS, pH 7.4. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Mouse Fibroblast Growth Factor-21 (rMuFGF-21) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability Lyophilized recombinant Mouse Fibroblast Growth Factor-21 (rMuFGF-21) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Fibroblast growth factor (FGF) 21 is a member of the FGF superfamily. It is most closely related to FGF19 and FGF23, sharing 30–35% amino acid sequence homology. The FGF19 subfamily comprises FGF19, FGF21, and FGF23, and all three FGF19 subfamily members have recently emerged as metabolic hormones involved in the regulation of glucose, lipid, bile acid, and phosphate metabolism[1]. FGF21 provides sustained glucose and lipid control, amelioration of insulin resistance, improvements in β-cell function and mass, and beneficial changes in other lipoprotein and cardiovascular risk factor profiles[2]. |
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