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Recombinant Human Hemofiltrate CC Chemokine-1/CCL14
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| 性状 | Recombinant Human Hemofiltrate CC Chemokine-1/CCL14 对人的单核细胞有较弱的活性，通过受体发挥作用，也能识别MIP-1 alpha。
Synonyms rHuHCC-1/CCL14; C-C motif chemokine 14; SCYA14 ; 重组人 CC 趋化因子14 Species Human Source E. coli Accession Q16627 Gene ID 6358 Molecular Weight Approximately 8.4 kDa AA Sequence TESSSRGPYH PSECCFTYTT YKIPRQRIMD YYETNSQCSK PGIVFITKRG HSVCTNPSDK WVQDYIKDMK EN Biological Activity The ED50 is <25 μg/mL as measured by CHO cells transfected with human CCR5, corresponding to a specific activity of >40 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Hemofiltrate CC Chemokine-1/CCL14 (rHuHCC-1/CCL14) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Hemofiltrate CC Chemokine-1/CCL14 (rHuHCC-1/CCL14) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Human Hemofiltrate CC Chemokine-1/CCL14 (HCC-1) is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma. HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-lot. It induces intracellular Ca2+ changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T lymphocytes, neutrophils, and eosinophil leukocytes. In addition, HCC-1 enhances the proliferation of CD34+ myeloid progenitor cells. It is as effective as MIP-1α, but about 100-fold less potent[1]. CCL14 regulate extracellular matrix and adhesion molecules in the trophoblast[2]. |
| 贮存 |
- Recombinant Rat GRO beta/CXCL2
- Recombinant Human GRO gama/CXCL3
- Recombinant Mouse Heparin-Binding EGF-like Growth Factor
- Recombinant Human Hemofiltrate CC Chemokine-1/CCL14
- Recombinant Human Hemofiltrate CC Chemokine-4/CCL16
- Recombinant Human I-309/CCL1
- Recombinant Human Interferon Omega
- Recombinant Rat Insulin-like Growth Factor-I
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