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Recombinant Human I-309/CCL1

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132714-10 μg 0 ￥3800 请登录
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1308132714-50 μg 0 ￥9800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human I-309/CCL1 通过与细胞表面的CCR8趋化因子受体相互作用，吸引单核细胞、自然杀伤细胞、未成熟的B细胞核树突状细胞。
Synonyms
rHuI-309/CCL1; C-C motif chemokine 1; SCYA1 ; 重组人I-309/CCL1
Species
Human

Source
E. coli

Accession
P22362

Gene ID
6346

Molecular Weight
Approximately 8.5 kDa

AA Sequence
SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK

Biological Activity
The ED50 is <1 μg/mL as measured by CHO-K1/Gα15/hCCR8 cells (human Gα15 and human CCR8 stably expressed in CHO-K1 cells).

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human I-309/CCL1 (rHuI-309/CCL1) to 100 μg/mL using ddH2O or PBS.

Storage & Stability
Lyophilized recombinant Human I-309/CCL1 (rHuI-309/CCL1) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Human I-309/CCL1 is a monocytec hemoattractant[1]. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. The CC chemokine I-309 is the only agonist that selectively induced intracellular Ca2+ mobilization and chemotaxis in receptor-transfected 300-19 cells. TER1 (ChemR1 or CKR-L1) is the receptor for I-309, and we propose to call this receptor CCR8 in agreement with the current nomenclature for chemokine receptors[2].
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