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Recombinant Human Interleukin-18 Binding Protein (CHO-expressed)
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| 性状 | Recombinant Human Interleukin-18 Binding Protein (CHO-expressed) 是 Th1 细胞因子应答的调节剂。
Synonyms rHuIL-18BP; Tadekinig-alfa; IL18BP Species Human Source CHO Accession O95998 Gene ID 10068 Molecular Weight 42-44 kDa AA Sequence TPVSQTTTAA TASVRSTKDP CPSQPPVFPA AKQCPALEVT WPEVEVPLNG TLSLSCVACS RFPNFSILYW LGNGSFIEHL PGRLWEGSTS RERGSTGTQL CKALVLEQLT PALHSTNFSC VLVDPEQVVQ RHVVLAQLWA GLRATLPPTQ EALPSSHSSP QQQG Biological Activity The ED50 is <30 ng/mL as measured by KG-1 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-18 Binding Protein (CHO-expressed) (rHuIL-18BP) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Human Interleukin-18 Binding Protein (CHO-expressed) (rHuIL-18BP) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background IL18BP (Interleukin-18 Binding Protein) is an early signal in the development of T-lympho-cyte helper type 1 (Th1) responses[1]. IL18BP shares many characteristics with soluble cytokine receptors of the IL1 family in that the protein exhibits specificity for IL18, belongs to the immunoglobulin-like class of receptors and has limited amino acid sequences with those of the IL1 receptor type II. IL18BP suppresses the production of IFNγ resulting in reduced T-helper type 1 immune responses. Two human IL18BP isoforms exhibit the greatest affinity for IL18 with a rapid on-rate, a slow off-rate and a dissociation constant (kDa) of 399 pM. The two other isoforms with an incomplete immunoglobulin domain are unable to neutralise IL18[2]. |
| 贮存 |
- Recombinant Rhesus Macaque Interleukin-1 beta
- Recombinant Mouse Interleukin-12 (CHO-expressed)
- Recombinant Human Interleukin-17F
- Recombinant Rat Interleukin-18
- Recombinant Human Interleukin-18 Binding Protein (CHO-expressed)
- Recombinant Human Interleukin-19
- Recombinant Mouse Interleukin-19
- Recombinant Human Interleukin-20
- Recombinant Human Interleukin-2 Receptor alpha, His (HEK293-expressed)
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