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Recombinant Human Interleukin-31

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132730-10 μg 0 ￥4600 请登录
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1308132730-50 μg 0 ￥14800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Interleukin-31是一种新型辅助T细胞衍生的细胞因子，在过敏性皮肤炎症和特应性皮炎中发挥重要作用。
Synonyms
rHuIL-31; IL31 ; 重组人白细胞介素-31
Species
Human

Source
E. coli

Accession
Q6EBC2

Gene ID
386653

Molecular Weight
Approximately 15.8 kDa

AA Sequence
SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T

Biological Activity
The ED50 is <5 ng/mL as measured by human U-87 MG cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-31 (rHuIL-31) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA.

Storage & Stability
Lyophilized recombinant Human Interleukin-31 (rHuIL-31) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Interleukin-31 (IL-31), which is preferentially produced by T helper type 2 cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases[1]. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin[2].
贮存
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