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Recombinant Human CD47, Fc Chimera (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132848-10 μg 0 ￥2400 请登录
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1308132848-50 μg 0 ￥6400 请登录
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别 名
Cas号
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分子式
分子量
产品参数
性状 Recombinant Human CD47, Fc Chimera (HEK293-expressed) 是在 HEK293 中产生的 C-末端标记 IgG1 Fc 片段的多肽链。CD47 是癌症免疫疗法的重要靶标。
Synonyms
rHuCD47, Fc Chimera; MER6; IAP; OA3
Species
Human

Source
HEK 293

Accession
Q08722

Gene ID
961

Molecular Weight
60-65 kDa

AA Sequence
QLLFNKTKSV EFTFCNDTVV IPCFVTNMEA QNTTEVYVKW KFKGRDIYTF DGALNKSTVP TDFSSAKIEV SQLLKGDASL KMDKSDAVSH TGNYTCEVTE LTREGETIIE LKYRVVSWFS P

Biological Activity
2 µg/mL (100 µL/well) of immoblized recombinant human SIRPa-His can bind human CD47-Fc with a linear range of 0.25-185 ng/mL.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human CD47, Fc Chimera (HEK293-expressed) (rHuCD47, Fc Chimera) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human CD47, Fc Chimera (HEK293-expressed) (rHuCD47, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Targeting CD47 is in the spotlight of cancer immunotherapy. Blocking CD47 triggers the recognition and elimination of cancer cells by the innate immunity. The CD47/SIRP-α axis has been established as an important regulator of innate anti-cancer immunity, with many if not all malignancies overexpressing the receptor CD47 that binds to phagocyte-expressed SIRP-α[1].
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