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Recombinant Human Bone Morphogenetic Protein-3B

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132845-10 μg 0 ￥2200
- +
1308132845-50 μg 0 ￥4200
- +
偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。
别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Bone Morphogenetic Protein-3B 属于转化生长因子 β 超家族，与骨形态发生蛋白-3 (BMP3) 密切相关。Recombinant Human Bone Morphogenetic Protein-3B 在头部形成中起作用，且在骨骼形态发生中具有多种作用。
Synonyms
rHuBMP-3B; BIP; BMP-3B; GDF-10
Species
Human

Source
E. coli

Accession
P55107

Gene ID
2662

Molecular Weight
Approximately 25.1 kDa

AA Sequence
MQWDEPRVCS RRYLKVDFAD IGWNEWIISP KSFDAYYCAG ACEFPMPKIV RPSNHATIQS IVRAVGIIPG IPEPCCVPDK MNSLGVLFLD ENRNVVLKVY PNMSVDTCAC R

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 4 mM HCl.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Bone Morphogenetic Protein-3B (rHuBMP-3B) to 100 µg/mL using 4 mM HCl.

Storage & Stability
Lyophilized recombinant Human Bone Morphogenetic Protein-3B (rHuBMP-3B) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
The transforming growth factor-beta (TGF-beta) superfamily includes more than 30 members which have a broad array of biological activities. TGF-beta superfamily ligands bind to type II and type I serine/threonine kinase receptors and transduce signals via Smad proteins. Receptor-regulated Smads (R-Smads) can be classified into two subclasses, i.e. those activated by activin and TGF-beta signaling pathways (AR-Smads), and those activated by bone morphogenetic protein (BMP) pathways (BR-Smads). The numbers of type II and type I receptors and Smad proteins are limited. Thus, signaling of the TGF-beta superfamily converges at the receptor and Smad levels. In the intracellular signaling pathways, Smads interact with various partner proteins and thereby exhibit a wide variety of biological activities. Moreover, signaling by Smads is modulated by various other signaling pathways allowing TGF-beta superfamily ligands to elicit diverse effects on target cells. Perturbations of the TGF-beta/BMP signaling pathways result in various clinical disorders including cancers, vascular diseases, and bone disorders[1].
贮存
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的，不可用于人类或动物的临床诊断或者治疗，非药用，非食用。
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