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Recombinant Human CD47, His (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132849-10 μg 0 ￥2400
- +
1308132849-50 μg 0 ￥6400
- +
偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。
别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human CD47, His (HEK293-expressed) 是在 HEK293 中产生的带有 His 标签的多肽链。CD47 是癌症免疫疗法的重要靶标。
Synonyms
rHuCD47, His; CD47; MER6; IAP; OA3
Species
Human

Source
HEK 293

Accession
Q08722

Gene ID
961

Molecular Weight
35-40 kDa

AA Sequence
QLLFNKTKSV EFTFCNDTVV IPCFVTNMEA QNTTEVYVKW KFKGRDIYTF DGALNKSTVP TDFSSAKIEV SQLLKGDASL KMDKSDAVSH TGNYTCEVTE LTREGETIIE LKYRVVSWFS PHHHHHH

Biological Activity
2 µg/mL (100 µL/well) of immoblized recombinant human CD47-His can bind human SIRPa-Fc with a linear range of 20-65 ng/mL.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human CD47, His (HEK293-expressed) (rHuCD47, His) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human CD47, His (HEK293-expressed) (rHuCD47, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Targeting CD47 is in the spotlight of cancer immunotherapy. Blocking CD47 triggers the recognition and elimination of cancer cells by the innate immunity. The CD47/SIRP-α axis has been established as an important regulator of innate anti-cancer immunity, with many if not all malignancies overexpressing the receptor CD47 that binds to phagocyte-expressed SIRP-α[1].
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