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Recombinant Human Fibroblast Growth Factor 10, His
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| 性状 | Recombinant Human Fibroblast Growth Factor 10, His 是带有 His 标签的多肽链。FGF-10 是结合肝素的生长因子，属于 FGF 家族。
Synonyms rHuFGF-10, His; Fibroblast Growth Factor-10; Keratinocyte growth factor-2 Species Human Source E. coli Accession O15520 Gene ID 2255 Molecular Weight Approximately 21.4 kDa AA Sequence MNHKVHHHHH HMDDDDKMLG QDMVSPEATN SSSSSFSSPS SAGRHVRSYN HLQGDVRWRK LFSFTKYFLK IEKNGKVSGT KKENCPYSIL EITSVEIGVV AVKAINSNYY LAMNKKGKLY GSKEFNNDCK LKERIEENGY NTYASFNWQH NGRQMYVALN GKGAPRRGQK TRRKNTSAHF LPMVVHS Biological Activity The ED50 is <20 ng/mL as measured by 4MBr-5 cells, corresponding to a specific activity of >5 × 104 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Fibroblast Growth Factor 10, His (rHuFGF-10, His) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Fibroblast Growth Factor 10, His (rHuFGF-10, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease. Alternatively, congenital airway abnormalities attributed to FGF10 mutations increase the risk of chronic airway disease in adulthood. FGF10 also maintains progenitor cell populations in the airway and promotes alveolar type 2 cell expansion and differentiation following injury. Here we review the cellular and molecular mechanisms linking FGF10 to multiple lung diseases, from bronchopulmonary dysplasia in extremely preterm neonates, cystic fibrosis in children, and chronic adult lung disorders. Understanding the connections between FGF10 and lung diseases may lead to exciting new therapeutic strategies[1]. |
| 贮存 |
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