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Recombinant Human Fibroblast Growth Factor 21, His (CHO-expressed)

英文名：
Cas号：
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货号 规格 货期 库存 价格 会员价 订购
1308132858-10 μg 0 ￥3200 请登录
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1308132858-50 μg 0 ￥7800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Fibroblast Growth Factor 21, His (CHO-expressed) 是 CHO 细胞中产生的 C-末端含 His 标签的多肽链。是一种成纤维细胞生长因子 (FGF)，可作为代谢调节剂，具有多重效应。
Synonyms
rHuFGF-21, His; FGF21
Species
Human

Source
CHO

Accession
Q9NSA1

Gene ID
26291

Molecular Weight
23-25 kDa

AA Sequence
HPIPDSSPLL QFGGQVRQRY LYTDDAQQTE AHLEIREDGT VGGAADQSPE SLLQLKALKP GVIQILGVKT SRFLCQRPDG ALYGSLHFDP EACSFRELLL EDGYNVYQSE AHGLPLHLPG NKSPHRDPAP RGPARFLPLP GLPPALPEPP GILAPQPPDV GSSDPLSMVG PSQGRSPSYA SHHHHHH

Biological Activity
The ED50 is <0.3 μg/mL as measured by NIH-3T3 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Fibroblast Growth Factor 21, His (CHO-expressed) (rHuFGF-21, His) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human Fibroblast Growth Factor 21, His (CHO-expressed) (rHuFGF-21, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Human Fibroblast Growth Factor 21 (FGF21) acts in an endocrine mannerand and is a metabolic regulator with pleiotropic effects. FGF21 possesses protective effects in the cardiovascular system, primarily due to metabolic effects other thanmaintaining energy homoeostasis. FGF21 is also involved inseveral processes, including reducing arteriosclerotic plaque formation in major vessels and protecting themyocardium from injuries caused by infarction, ischaemia-reperfusion, isoproterenol-induced hypertrophy anddiabetic lipotoxicity. In addition, FG2F1 induces these effects by atten-uating remodelling-related inflammation and oxidativestress and promoting myocardial energy metabolism, as well as by preventing lipid- or diabetes-induced cardiaccell apoptosis. FGF21 functions via its interaction with FGF receptors (FGFRs), with the assistance of the co-receptor β-Klotho. Structurally, the FGFRs are divided into four isoforms, FGFR1-FGFR4[1].
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