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Recombinant Human Interleukin-6 Receptor alpha (Sf9 insect cells-expressed)

英文名：
Cas号：
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1308132889-50 μg 0 ￥3800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Interleukin-6 Receptor alpha (Sf9 insect cells-expressed) 是一类 I 型跨膜糖蛋白，与 I 型跨膜信号转导蛋白gp130 (CD130)形成复合物，调控 IL-6 的生物学活性。
Synonyms
rHuIL-6 Receptor α; gp80; CD126
Species
Human

Source
Sf9 insect cells

Accession
P08887

Gene ID
3570

Molecular Weight
Approximately 50 kDa

AA Sequence
HHHHHHDDDD KLAPRRCPAQ EVARGVLTSL PGDSVTLTCP GVEPEDNATV HWVLRKPAAG SHPSRWAGMG RRLLLRSVQL HDSGNYSCYR AGRPAGTVHL LVDVPPEEPQ LSCFRKSPLS NVVCEWGPRS TPSLTTKAVL LVRKFQNSPA EDFQEPCQYS QESQKFSCQL AVPEGDSSFY IVSMCVASSV GSKFSKTQTF QGCGILQPDP PANITVTAVA RNPRWLSVTW QDPHSWNSSF YRLRFELRYR AERSKTFTTW MVKDLQHHCV IHDAWSGLRH VVQLRAQEEF GQGEWSEWSP EAMGTPWTES RSPPAENEVS TPMQALTTNK DDDNILFRDS ANATSLPVQD

Biological Activity
The ED50 is <50 ng/mL as measured by M1 cells, corresponding to a specific activity of >2 × 104 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-6 Receptor alpha (Sf9 insect cells-expressed) (rHuIL-6 Receptor α) to 100 µg/mL using ddH2O.

Storage & Stability
Lyophilized recombinant Human Interleukin-6 Receptor alpha (Sf9 insect cells-expressed) (rHuIL-6 Receptor α) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
It is found that soluble IL-6 receptor alpha-subunit (IL-6Ralpha), with their constitutive IL-6 synthesis, stimulated endothelial cells to synthesize E-selectin, intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, IL-6, and IL-8, and to bind neutrophils. Neutrophils express significant amounts of IL-6Ralpha and upon stimulation shed it: this material activates endothelial cells through a newly constituted IL-6 receptor. Retrograde signaling from PMN activated in the extravascular compartment to surrounding endothelial cells will recruit more and a wider variety of leukocytes. The limiting signal is a soluble receptor, not a cytokine[1].
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