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Recombinant Human Interleukin-2 Receptor alpha/CD25, Fc Chimera (HEK293-expressed)

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产品参数
性状 Recombinant Human Interleukin-2 Receptor alpha/CD25, Fc Chimera (HEK293-expressed) 是白细胞介素-2 受体的一个亚单位，通过调节 IL-2R 对配体的亲和力，在调节 IL-2 介导的反应中发挥着重要作用。
Synonyms
rHuIL-2R α/CD25, Fc Chimera; TAC antigen; IL-2-RA; IL-2 R alpha; IL-2Rα; IL2RA ; 重组人白介素-2 受体 α/CD25 Fc 嵌合体 (HEK293 细胞表达)
Species
Human

Source
HEK 293

Accession
P01589

Gene ID
3559

Molecular Weight
65-75 kDa

AA Sequence
ELCDDDPPEI PHATFKAMAY KEGTMLNCEC KRGFRRIKSG SLYMLCTGNS SHSSWDNQCQ CTSSATRNTT KQVTPQPEEQ KERKTTEMQS PMQPVDQASL PGHCREPPPW ENEATERIY HFVVGQMVYY QCVQGYRALH RGPAESVCKM THGKTRWTQP QLICTGEMET SQFPGEEKPQ ASPEGRPESE TSC

Biological Activity
5 µg/mL (100 µL/well) of immoblized recombinant human IL-2 can bind human CD25/IL-2Rα-Fc with a linear range of 1.2-11 ng/mL.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-2 Receptor alpha/CD25, Fc Chimera (HEK293-expressed) (rHuIL-2R α/CD25, Fc Chimera) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human Interleukin-2 Receptor alpha/CD25, Fc Chimera (HEK293-expressed) (rHuIL-2R α/CD25, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
IL-2 binds with high affinity to a receptor consisting of three subunits: IL-2Rα (CD25), IL-2Rβ (CD122) and γc (CD132). Alpha subunit plays a critical role in regulating the IL-2-mediated responses by modulating the affinity of the IL-2R for the ligand. Then, two β and γ subunits initiate the signal transduction process via cytoplasmic tails[1].
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