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Alpha-Synuclein Phospho (pY125) (SNCA)
英文名：Rabbit Monoclonal Antibody
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113327-100ul | 0 | ￥3500 | 请登录 |
| 别 名 | SNCA antibody, MGC110988 antibody, NACP antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, Alpha-synuclein antibody, Non-A beta component of AD amyloid antibody, Non-A4 component of amyloid precursor antibody |
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| 产品参数 | 【产品介绍】Alpha-Synuclein is expressed predominantly
in brain, where it is concentrated in presynaptic nerve terminals (1). The deposition of the abundant presynaptic brain protein alpha-synuclein as fibrillary aggregates in neurons or glial cells is a hallmark lesion in a subset of neurodegenerative disorders. These disorders include Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies. Phosphorylation of alpha-synuclein at Ser 129 promoted fibril formation in vitro and these results highlight the importance of phosphorylation of filamentous proteins in the pathogenesis of neurodegenerative disorders (2). Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin. It is hypothesized that parkin and alpha-synculein interact functionally, namely, that parkin ubiquitinates alpha-synuclein normally and that this process is altered in autosomal recessive PD (3). Recommended Applications WB, ICC Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 ICC: 1:100 - 250 Species Reactivity * Human *Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on HeLa cell lysates using anti-Phospho-Alpha-Synuclein (pY125) RabMAb (cat. #3932-1). Cells were either (A) untreated (B) treated with pervanadate. Specificity A phospho specific peptide corresponding to residues surrounding tyrosine 125 of human Alpha-Synuclein was used as an immunogen. This antibody only detects Alpha-Synuclein phosphorylated at tyrosine 125. |
| 性状 | 【反应特异性】Human
【克隆 ID】EPR2179(2) 【用途】WB , ICC 【抗原分子量】18kDa |
| 贮存 | Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt |
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