BLNK Rabbit Antibody

英文名:Rabbit Monoclonal IgG
Cas号:
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别 名 Cytoplasmic adapter protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】B-cell linker protein (BLNK, also known
as SLP65, BASH, a n d BCA) is a B cell adapt o r that
plays an imp o r tant role in B cell development a n d
in BCR-signal transduction. Since BLNK does not encode
any intrinsic enzymatic activity, its function is to
serve as a scaffold f o r assembling
macromolecular complexes which includes enzymes
(PLC gamma, Vav a n d Btk) a n d additional linker
proteins (Grb2 a n d Nck) (1-3) . In addition, BLNK
binds Btk a n d is required f o r activation of
the transcription fact o r NF-κB. Tyrosine phosph
o r ylation of BLNK by Syk provides specific docking sites
f o r these SH2-containing effect o r proteins which in
turn permits phosph o r ylation a n d / o r activation
of their respective signaling pathways.


WB: 1:500
IHC: 1:50
IP: 1:20



A. Western blot analysis on Raji cell lysate using
anti-BLNK (RabMAb (cat. #1597-1), 1:500 dilution.

B. Immunohistochemical analysis of paraffin-embedded
human spleen tissue using anti-BLNK RabMAb (cat. # 1597-1).
性状 【反应特异性】Human , Mouse
【克隆 ID】Y491
【用途】WB , IHC , IP
【抗原分子量】68/70 kDa
贮存
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