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生化科研试剂 >> 抗体产品 >> 一抗 |
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B-Raf Phospho (pT401) Rabbit Monoclonal IgG |
别 名: |
p94, v-Raf murine sarcoma viral oncogene homolog B1 |
货号 |
品名 |
规格 |
包装 |
单价 |
货期 |
库存 |
1227177578 |
B-Raf Phospho (pT401) |
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100ul |
询价 |
现货 |
3天 |
提示信息:偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体,下单前请联系客服。 |
性 状: |
【反应特异性】Human , Mouse , Rat 【克隆 ID】EPR2208Y 【用途】WB , IP 【抗原分子量】94 kDa |
质量标准: |
【产品介绍】B-Raf, also know as c-Rmil, is a Serine/Threonine protein kinase member of the Raf family which includes Raf-1 a n d A-Raf. B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus (1). Composed of three conserved region (CR1, CR2, CR3) B-Raf is expressed primarily in the brain a n d in the nervous system (2). It has been observed that MAPK is activated by B-Raf in response to nerve growth fact o r (3). M o r e than 60% of malignant melanomas were found to contain a specific mutation, B-Raf (V599E) the product of which possesses constitutive kinase activity (4). Mutations in B-Raf have also been identified in lung cancer a n d non-Hodgkin lymphoma. WB: 1:1000 - 5000 ICC: 1:100 – 250 IP: 1:20
A. Western blot analysis on PC-12 cell lysates using anti-Phospho-B-Raf (p401) RabMAb (cat. #2298-1), 1:5000 dilution. Cells were either (A) untreated (B) treated with TPA. |
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