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Crk/p38 (CRK)

英文名：Rabbit Monoclonal Antibody
Cas号：
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别 名 CRK antibody, CRKII antibody, Adapter molecule crk antibody, Proto-oncogene c-Crk antibody, p38 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Crk (p38) are adaptor proteins, composed
mostly of SH2 and SH3 domains, which play a key role
in cellular signaling by mediating the construction
of protein complexes and also by managing
cell proliferation, differentiation, and migration (1).
They are critical integrators of upstream signals for
cell invasion and migration in human cancer cell lines.
Crk is believed to be a regulator of invasive
responses because increased levels of the protein have
been observed in multiple human cancers (2). In vivo
studies have demonstrated that decreased levels of
Crk remarkably inhibits tumor formation and its
invasive growth (3). Crk associates with ERM family
proteins (including ezrin, radixin, and moesin),
activates RhoA, and promotes cell motility toward
hyaluronic acid (4).


Recommended Applications

WB, ICC, IP, FC
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
ICC: 1:50 - 100
IP: 1:10 - 100
FC: 1:100 - 500
Species Reactivity *

Human, Mouse, Rat

*Species cross-reactivity is based on WB analysis.

Products Data

Western blot analysis on (A) HepG2, (B) K562, (C) HeLa,
and (D) Jurkat cell lysates using anti-Crk/p38 RabMAb
(cat. #5359-1).
Flow cytometric analysis of permeabilized HepG2 cells
using anti-Crk/p38 RabMAb (red) (catalog # 5359-1) or
a rabbit IgG (negative) (green).

Specificity

A synthetic peptide corresponding to residues in human Crk/p38 was used as an immunogen.
性状 【反应特异性】Human , Mouse , Rat
【克隆 ID】EPR4984(2)
【用途】WB , ICC , FC , IP
【抗原分子量】38kDa
贮存 Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt
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