EGFR (C-term)

英文名:Rabbit Monoclonal IgG
Cas号:
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别 名 Recept o r tyrosine-protein kinase ErbB-1
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Epidermal growth fact o r recept o r (EGFR) is
a 170 kDa transmembrane glycoprotein recept o r
tyrosine kinase that, activated by epidermal growth fact
o r (EGF), affects cell growth a n d differentiation
(1). Binding of EGF o r TGF alpha to EGFR activates
tyrosine kinase activity of the recept o r (2). The
carboxy terminal tyrosine residues on EGFR, Tyr 1068,
Tyr 1148, a n d Tyr 1173, are the maj o r sites
of autophosph o r ylation, which occurs as a result of
EGF binding (3). Once activated, EGFR
phosphotyrosines Y-1068 a n d Y-1173 mediate the binding
of Grb2 to the EGFR. Another autophosph o r ylation
site, Tyr 1086, is situated within the cytoplasmic domain,
a n d is phosph o r ylated to a higher extent by c-Src
than by EGFR (4).


WB: 1:10,000
ICC: 1:50
Flow Cytometry: 1:10
IP: 1:30


A. Western blot analysis on A431 cell lysate using
anti-EGFR (C-term) RabMAb (cat. #2235-1); dilution 1:10,000.

B. Immunoflu o r escent staining of A431 cells
using anti-EGFR (C-term) RabMAb (cat. #2235-1).
性状 【反应特异性】Human
【克隆 ID】E235
【用途】WB , ICC , FC , IP
【抗原分子量】170 kDa
贮存
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