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GCN2 (EIF2AK4)
英文名：Rabbit Monoclonal Antibody
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113623-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | EIF2AK4 antibody, GCN2 antibody, KIAA1338 antibody, Eukaryotic translation initiation factor 2-alpha kinase 4 antibody, GCN2-like protein antibody |
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| 产品参数 | 【产品介绍】In eukaryotic cells, protein synthesis
is regulated in response to various environmental stresses by phosphorylating the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha). Four different eIF2alpha kinases have been identified in mammalian cells, the heme-regulated inhibitor (HRI), the interferon-inducible RNA-dependent kinase (PKR) and the endoplasmic reticulum-resident kinase (PERK) and GCN2, which was previously characterized from Saccharomyces cerevisiae, Drosophila melanogaster and Neurospora crassa. GCN2 is the unique eIF2alpha kinase present in all eukaryotes from yeast to mammals (1). GCN2, a sensor of amino acid deficiency, plays a key role in yeast and mammals in modulating amino acid metabolism as part of adaptation to nutrient deprivation. (2). Results demonstrate that PERK and GCN2 function to cooperatively regulate eIF2alpha phosphorylation and cyclin D1 translation after unfolded protein response pathway activation (3). Recommended Applications WB, IHC, ICC, FC Applications and Recommended Dilution Factors WB: 1:1,000 - 10,000 IHC: 1:100 - 250 ICC: 1:250 - 500 FC: 1:100 - 500 Species Reactivity * Human *Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on (A) HeLa, (B) 293T, (C) Molt-4, and (D) A549 cell lysates using anti-GCN2 RabMAb (cat. #5417-1). Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-GCN2 RabMAb (cat. #5417-1). Specificity A synthetic peptide corresponding to residues near the N-terminus of human GCN2 was used as an immunogen. |
| 性状 | 【反应特异性】Human
【克隆 ID】EPR5970(2) 【用途】WB , IHC , ICC , FC 【抗原分子量】220kDa |
| 贮存 | Storage Condition and Buffer Store at -20° C. Buffer: PBS (pH 7.2), 0.01% sodium azide, 50% Glycerol and 0.05% BSA. Stable for 12 months from date of receipt. |
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