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HSD17B1 (C-term)

英文名：HSD17B1 (C-term)
Cas号：
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货号 规格 货期 库存 价格 会员价 订购
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别 名 HSD17B1 antibody, EDH17B2 antibody, EDHB17 antibody, HSD17 antibody, MGC138140 antibody, SDR28C1 antibody, Estradiol 17-beta-dehydrogenase 1 antibody, E2DH antibody, Placental 17-beta-hydroxysteroid dehydrogenase antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】The principal human estrogen, 17 beta-
estradiol, is a potent stimulator of certain
endocrine-dependent forms of breast cancer. Because
human estrogenic 17 beta-hydroxysteroid
dehydrogenase (HSD17B1) catalyzes the last step in
the biosynthesis of 17 beta-estradiol from the less
potent estrogen, estrone, it is an attractive target for
the design of inhibitors of estrogen production and
tumor growth (1). It is concluded that the
steroid-binding site of human placental HSD17B1 contains
a histidine residue which proximates the upper A-ring
region of the steroid as it undergoes the reversible
binding step (2). Human estrogenic HSD17B1 is
an NADP(H)-preferring enzyme. It possesses 11- and
4-fold higher specificity toward NADP(H) over NAD(H)
for oxidation and reduction, respectively, as
demonstrated by kinetic studies (3). Defects in
the conversion of androstenedione to testosterone in
the fetal testes by the enzyme HSD17B1 give rise to
genetic males with female external genitalia (4)

Recommended Applications
WB, IHC, ICC, FC
Applications and Recommended Dilution Factors
WB: 1:500
IHC: 1: 100 - 250
ICC: 1:50
FC: 1:40
Species Reactivity *
Human
*Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on human placenta lysate
using anti-HSD17B1 RabMAb (cat. # 2127-1), dilution 1:500.

Immunohistochemical analysis of paraffin-embedded
human placenta tissue using anti-HSD17B1 RabMAb
(cat.# 2127-1).

Specificity
A synthetic peptide corresponding to residues on
the C-terminus of human HSD17B1 was used as an immunogen.
性状 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human
【克隆 ID】EP1681Y
【用途】WB , IHC , ICC , FC
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】35kDa
贮存 Store at -20 °C. 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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