IDO (IDO1)

英文名:IDO (IDO1)
Cas号:
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别 名 IDO1 antibody, IDO antibody, IDO-1 antibody, INDO antibody, Indoleamine 2,3-dioxygenase 1 antibody, Indoleamine-pyrrole 2,3-dioxygenase antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】T lymphocytes undergo proliferation arrest
when exposed to tryptophan shortage, which can be
provoked by indoleamine 2,3-dioxygenase (IDO), an
enzyme that is expressed in placenta and
catalyzes tryptophan degradation. Here we show that
most human tumors constitutively express IDO.
Results suggest that the efficacy of therapeutic
vaccination of cancer patients might be improved
by concomitant administration of an IDO inhibitor
(1). Certain macrophages, induced to express IDO in
response to interferon-gamma and other signals
from activating T cells, inhibit T-cell proliferation
in vitro by rapidly consuming tryptophan. Because IDO
is also expressed by human syncytiotrophoblast cells
and systemic tryptophan concentration falls during
normal pregnancy, it is believed that IDO expression at
the maternal-fetal interface is necessary to
prevent immunologic rejection of the fetal allografts (2).

Recommended Applications
WB
Applications and Recommended Dilution Factors
WB: 1:1000 - 10,000
Species Reactivity *
Human
*Cross reactivity determined by western blot only.
Products Data

A. Fig 1. Western blot analysis on Hela + IFN-gamma
cell lysate using anti-IDO RabMAb (cat. # 2121-1),
dilution 1:5000.

Specificity
A synthetic peptide corresponding to residues within
human IDO was used as an immunogen.
性状 【产品类型】Rabbit Monoclonal Antibody
【反应特异性】Human
【克隆 ID】EPR1230Y
【用途】WB
【产品性状】
【阳性对照】
【产品浓度】
【细胞定位】
【抗原分子量】42kDa
贮存 Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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