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IRS-2 (Pan)
英文名：IRS-2 (Pan)
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114463-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | IRS-2 |
| Cas号 | |
| M D L | |
| 分子式 | |
| 分子量 | |
| 产品参数 | 【产品介绍】Insulin recept o r substrates (IRS), the maj
o r intracellular substrates of the insulin recept o r (IR), are adapt o r proteins that transduce signals from the IR to downstream effect o r s that are imp o r tant f o r the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosph o r ylated on multiple tyrosine residues. Once phosph o r ylated, IRS proteins bind a n d activate Grb-2, SHP2 a n d the PI3-K p85 subunit (2-3). Sequences of IRS-2 a n d IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain a n d a phosphotyrosine-binding domain, a n d a po o r ly conserved carboxy terminus containing several tyrosine phosph o r ylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, a n d may be essential f o r signaling by several recept o r systems such as insulin a n d cytokine (1). WB: 1:100,000 IHC: 1:100 250 IP: 1:50 A. Western blot analysis on 293 cell lysate using anti-IRS- 2 RabMAb (cat. #1849-1), dilution 1:100,000 B. Immunohistochemical staining of paraffin-embedded human kidney using anti-IRS-2 RabMAb (cat. #1849-1). |
| 性状 | 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human 【克隆 ID】EP976Y 【用途】WB , IHC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】185 kDa |
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