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JAK2 Phospho (pY1007/1008)
英文名：JAK2 Phospho (pY1007/1008)
Cas号：
Cas号：
检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308114465-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | Janus kinase 2, JAK-2 |
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| 产品参数 | 【产品介绍】Jak2 is a member of the Janus family
tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines a n d interferons. Jaks associate with cytokine recept o r s; upon lig a n d binding, Jaks phosph o r ylate the recept o r . The phosph o r ylated recept o r s are bound by SH2-containing proteins, one class of which is the signal transducers a n d activat o r s of transcription (STATs). Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Tyr1007/1008 of Jak2 are the homologous Tyr1054/1055 in Tyk2, a n d phosph o r ylation at these residues is needed f o r Tyk2 activation (3). A chromosomal aberration involving Jak2 is found in a f o r m of pre-B acute myeloid leukemia (4). WB: 1:5,000-10,000 IHC: 1:50-100 ICC: 1:50100 IP: 1:50 A. Western blot analysis of immunoprecipitation pellets from Jurkat cell lysate +GM-CSF (catalog #1477-1), dilution 1:50. B. Immunohistochemical analysis of paraffin-embedded human lung adenocarcinoma using anti-JAK-2 (pY1007/1008) RabMAb (catalog #1477-1). C. Dot Blot analysis on immunogen phospho-peptide (A) a n d non-phospho peptide (B) using anti-Jak2 (pY1007/1008) RabMAb (cat. # 1477-1) dilution 1:1,000 |
| 性状 | 【产品类型】Rabbit Monoclonal IgG
【反应特异性】Human , Mouse , Rat 【克隆 ID】E132 【用途】WB , IHC , ICC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】130 kDa |
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