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度伐单抗
英文名:Durvalumab
Cas号:1428935-60-7
Cas号:1428935-60-7
检测信息查询
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Cas号 | 1428935-60-7 |
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产品参数 | Description
Durvalumab (MEDI 4736) is an humanized anti-PD-L1 monoclonal antibody[1]. Durvalumab (MEDI4736) completely blocks the binding of PD-L1 to both PD-1 and CD80, with IC50s of 0.1 and 0.04 nM, respectively[2]. IC50 & Target IC50: 0.1 nM (PD-L1/PD-1), 0.04 nM (PD-L1/CD80)[2] |
性状 | Durvalumab (MEDI 4736) 是一种人源化的抗 PD-L1 蛋白单克隆抗体。Durvalumab (MEDI 4736) 完全阻断 PD-L1 与 PD-1 和 CD80 结合, IC50 分别为 0.1 和 0.04 nM。 |
贮存 | Storage Please store the product under the recommended conditions in the Certificate of Analysis. References [1]. Faiena I, et al. Durvalumab: an investigational anti-PD-L1 monoclonal antibody for the treatment of urothelial carcinoma. Drug Des Devel Ther. 2018 Jan 23;12:209-215. [2]. Stewart R, et al. Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody. Cancer Immunol Res. 2015 Sep;3(9):1052-62. |