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Recombinant Human Transforming Growth Factor β1
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| 性状 | TGFβ1是一种多功能细胞因子，参与胎儿发育，控制细胞生长和分化，诱导纤维化，引起免疫应答的抑制，参与血管生成，肿瘤的发展和炎症过程。
Synonyms TGF-beta-1; TGFB1; TGFB; rHuTGF-β1 Species Human Source CHO Accession P01137 Gene ID 7040 Molecular Weight Approximately 12 kDa AA Sequence ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS Biological Activity The ED50 is <0.2 ng/mL as measured by HT-2 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 50 mM NaAc, 50 mM NaCl, pH 5.0. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Transforming Growth Factor β1 (rHuTGF-β1) to 100 µg/mL using ddH2O or diluted with 50 mM Citrate. Storage & Stability Lyophilized recombinant Human Transforming Growth Factor β1 (rHuTGF-β1) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background TGFβ is released from degranulating platelets and secreted by all of the major cell types participating in the repair process, including lymphocytes, macrophages, endothelial cells, smooth muscle cells, epithelial cells, and fibroblasts. Mammals express three isoforms of TGFβdesignated TGFβI, TGFβ2, and TGFβ3; TGFβ1 is the most abundant isoform in all tissues, and in human platelets it is the only isoform of the peptide. Certain cells such as retinal pigment epithelial cells secrete predominantly TGFβ2, and certain body fluids such as the aqueous and vitreous of the eye, amniotic fluid, saliva, and breast milk contain principally TGFβ2. TGFβ3 is the least studied of the TGFβ isoforms. It has been isolated from human umbilical cord and is secreted from certain cells, including myoblast celllines; however, it is usually less abundant than either TGFβ1 or TGFβ2 in both tissue and cell extracts[1]. There are three fundamental directions of its activities: I. TGFβ1 regulates cell proliferation, growth, differentiation and cells movement. II. TGFβ1 has immunomodulatory effects. III. TGFβ1 has profibrogenic effects. TGFβ1 action can be local and systemic[2]. |
| 贮存 |
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- Recombinant Human Transforming Growth Factor β2
- Recombinant Human Transforming Growth Factor beta3 (HEK293-expressed)
- Recombinant Human Hepatocyte Growth Factor (CHO-expressed)
- Recombinant Human Fibroblast Growth Factor 18
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