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Recombinant Human Transforming Growth Factor β2

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132639-2 μg 0 ￥3700 请登录
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1308132639-10 μg 0 ￥5800 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Transforming Growth Factor β2是一种多功能细胞因子，参与控制细胞生长和分化，诱导纤维化，引起免疫应答的抑制，并在胚胎发育过程中起着至关重要的作用。
Synonyms
TGF-beta-2; Cetermin; G-TSF; TGFB2; Polyergin; rHuTGF-β2
Species
Human

Source
HEK 293

Accession
P61812

Gene ID
7042

Molecular Weight
Approximately 12.7 kDa

AA Sequence
ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS

Biological Activity
The ED50 is <0.2 ng/mL as measured by mouse HT-2 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 4 mM HCl.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Transforming Growth Factor β2 (rHuTGF-β2) to 100 µg/mL using ddH2O.

Storage & Stability
Lyophilized recombinant Human Transforming Growth Factor β2 (rHuTGF-β2) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
TGFβ is released from degranulating platelets and secreted by all of the major cell types participating in the repair process, including lymphocytes, macrophages, endothelial cells, smooth muscle cells, epithelial cells, and fibroblasts. Mammals express three isoforms of TGFβ designated TGFβI, TGFβ2, and TGFβ3; TGFβ1 is the most abundant isoform in all tissues, and in human platelets it is the only isoform of the peptide. Certain cells such as retinal pigment epithelial cells secrete predominantly TGFβ2, and certain body fluids such as the aqueous and vitreous of the eye, amniotic fluid, saliva, and breast milk contain principally TGFβ2. TGFβ3 is the least studied of the TGFβ isoforms. It has been isolated from human umbilical cord and is secreted from certain cells, including myoblast celllines; however, it is usually less abundant than either TGFβ1 or TGFβ2 in both tissue and cell extracts[1]. Transforming Growth Factor β2 mediates various cell-cell interactions that occur during embryonic development. It is previously shown that Transforming Growth Factor β2 mRNA is expressed at chondrogenic sites in the developing limb. When Transforming Growth Factor β2-soaked beads are implanted in the limb bud, extra digits are induced, and mice lacking Transforming Growth Factor β2 has minor skeletal defects in the limb[2].
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