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Recombinant Human Beta Defensin-3
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| 性状 | Recombinant Human Beta Defensin-3 是一种抗菌肽，对革兰氏阳性菌和革兰氏阴性菌均有抗菌活性，具有化学诱导剂的作用。
Synonyms rHuBD-3; DEFB-3; HBD3; Beta-defensin 103 ; 重组人 β-防御素-3 Species Human Source E. coli Accession P81534 Gene ID 55894 Molecular Weight Approximately 5.2 kDa AA Sequence GIINTLQKYY CRVRGGRCAV LSCLPKEEQI GKCSTRGRKC CRRKK Biological Activity The ED50 is <30 μg/mL as measured by anti-microbial activity against E.coli, corresponding to a specific activity of >33.3 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against 20 mM PBS, pH 7.4, 130 mM NaCl. Endotoxin Level <1 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Beta Defensin-3 (rHuBD-3) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability Lyophilized recombinant Human Beta Defensin-3 (rHuBD-3) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Human β-defensin-3 (HβD-3) is the most recently discovered member of the host defense peptide family. HβD-3 has been shown to exhibit antibacterial activities towards Gram-negative and Gram-positive bacteria as well as an ability to act as a chemo-attractant. HβD-3 is of special interest for structural and functional studies and also for possible pharmaceutical applications. It is also one among the identified human defensins that has the ability to undergo oligomerization[1]. |
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