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Recombinant Human Interleukin-1 beta (CHO-expressed)
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性状 | Recombinant Human Interleukin-1 beta (CHO-expressed) 能调控炎症反应,参与细胞增殖、分化、凋亡等多种细胞生命活动。
Synonyms rHuIL-1β; Catabolin; IL1F2; IL1B ; 重组人白细胞介素-1 β (CHO细胞表达) Species Human Source CHO Accession P01584 Gene ID 3553 Molecular Weight Approximately 17 kDa AA Sequence APVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS Biological Activity The ED50 is <10 pg/mL as measured by D10S cells, corresponding to a specific activity of >1.0 × 108 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-1 beta (CHO-expressed) (rHuIL-1β) to 100 μg/mL using ddH2O or PBS. Storage & Stability Lyophilized recombinant Human Interleukin-1 beta (CHO-expressed) (rHuIL-1β) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background IL-1β (Interleukin-1 beta) is a member of the interleukin 1 family of cytokines. IL-1β is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by IL-1β in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity[1]. |
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