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Recombinant Human Leptin

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132744-50 μg 0 ￥1800 请登录
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1308132744-100 μg 0 ￥2400 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human Leptin是脂肪细胞分泌的一种激素，通过抑制摄食和增加产热来帮助调节能量平衡。
Synonyms
rHuLeptin; Obesity protein; OB ; 重组人瘦素
Species
Human

Source
E. coli

Accession
P41159

Gene ID
3952

Molecular Weight
Approximately 16.0 kDa

AA Sequence
VPIQKVQDDT KTLIKTIVTR INDISHTQSV SSKQKVTGLD FIPGLHPILT LSKMDQTLAV YQQILTSMPS RNVIQISNDL ENLRDLLHVL AFSKSCHLPW ASGLETLDSL GGVLEASGYS TEVVALSRLQ GSLQDMLWQL DLSPGC

Biological Activity
The ED50 is <2 ng/mL as measured by human Leptin R transfected BaF3 murine proB cells, corresponding to a specific activity of >5.0 × 105 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level
<1 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Leptin (rHuLeptin) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA.

Storage & Stability
Lyophilized recombinant Human Leptin (rHuLeptin) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
A sensor (leptin production by adipose cells) monitors the size of the adipose tissue mass. Hypothalamic centers receive and integrate the intensity of the leptin signal through leptin receptors (LRb). Effector systems, including the sympathetic nervous system, control the two main determinants of energy balance-energy intake and energy expenditure[1]. Recessive mutations in the leptingene are associated with massive obesity in mice and humans, establishing a genetic basis for obesity. Leptin circulates in blood and acts on the brain to regulate food intake and energy expenditure. When fat mass falls, plasma leptin levels fall, stimulating appetite and suppressing energy expenditure until fat mass is restored. When fat mass increases, leptin levels increase, suppressing appetite until weight is lost. This system maintains homeostatic control of adipose tissue mass[2].
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