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Recombinant Human Insulin-like growth factor-binding protein 2, His (HEK-expressed)

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Cas号：
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Cas号
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分子式
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产品参数
性状 Recombinant Human Insulin-like growth factor-binding protein 2, His (HEK-expressed) 是高亲和力结合蛋白家族成员 (IGFBP1-6)，在中枢神经系统胰岛素样生长因子 (IGF) 调控中发挥调控作用。
Synonyms
rHuIGF-BP-2, His; IBP-2; IGFBP-2; BP2 ; 重组人胰岛素样生长因子结合蛋白 2 His (HEK 细胞表达)
Species
Human

Source
HEK 293

Accession
P18065

Gene ID
3485

Molecular Weight
6-20 kDa

AA Sequence
FRCPPCTPER LAACGPPPVA PPAAVAAVAG GARMPCAELV REPGCGCCSV CARLEGEACG VYTPRCGQGL RCYPHPGSEL PLQALVMGEG TCEKRRDAEY GASPEQVADN GDDHSEGGLV ENHVDSTMNM LGGGGSAGRK PLKSGMKELA VFREKVTEQH RQMGKGGKHH LGLEEPKKLR PPPARTPCQQ ELDQVLERIS TMRLPDERGP LEHLYSLHIP NCDKHGLYNL KQCKMSLNGQ RGECWCVNPN TGKLIQGAPT IRGDPECHLF YNEQQEARGV HTQRMQHHHH HH

Biological Activity
The ED50 is <2 µg/mL as measured by FDC-P1 cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human Insulin-like growth factor-binding protein 2, His (HEK-expressed) (rHuIGF-BP-2, His) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human Insulin-like growth factor-binding protein 2, His (HEK-expressed) (rHuIGF-BP-2, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Insulin-like Growth Factor Binding Protein 2 (IGFBP2) is a member of the family of high-affinity binding proteins (IGFBP1-6) and appears to play a governing role in Insulin-like Growth Factor (IGF) regulation in the central nervous system[1]. Insulin-like Growth Factor-Binding Proteins (IGFBPs) modulate the actions of secreted insulin-like growth facts (IGFs) by binding to them and increase the IGF halflife in the extracellular milieu and circulation by sequestering them in this bound form. IGFBPs either enhance or inhibit IGF actions on target cells; the individual IGFBPs either inhibit or potentiate IGF effects on osteoblasts in bone. Human Insulin-like Growth Factor-Binding Protein 5 (rhIGFBP-5) is a unique and most abundant IGFBP stored in bone, having a high specific binding affinity for hydroxyapatite and extracellular matrix proteins, therefore fixing it and its bound IGFs within bone. rhIGFBP-5 consistently stimulates osteoblast cell proliferation in vitro, thus increasing the number of osteoblasts[2].
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