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Recombinant Mouse Thrombopoietin, His (HEK293-expressed)

英文名：
Cas号：
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1308132930-10 μg 0 ￥4200 请登录
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1308132930-50 μg 0 ￥12400 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Mouse Thrombopoietin, His (HEK293-expressed) 是一种在 HEK293 细胞中产生的带有标签的重组小鼠血小板生成素 (TPO)，在 HEK293 细胞中产生。Recombinant Mouse Thrombopoietin 是巨核细胞生长和分化的主要调节因子。
Synonyms
rMuThpo, His; C-mpl ligand; MGDF ; 重组小鼠血小板生成素，His 标签 (HEK293 细胞表达)
Species
Mouse

Source
HEK 293

Accession
P40226

Gene ID
21832

Molecular Weight
62-70 kDa

AA Sequence
SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKFPNRTSG LLETNFSVTA RTAGPGLLSR LQGFRVKITP GQLNQTSRSP VQISGYLNRT HGPVNGTHGL FAGTSLQTLE ASDISPGAFN KGSLAFNLQG GLPPSPSLAP DGHTPFPPSP ALPTTHGSPP QLHPLFPDPS TTMPNSTAPH PVTMYPHPRN LSQETHHHHH H

Biological Activity
The ED50 is <2 ng/mL as measured by MO7e cells.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Mouse Thrombopoietin, His (HEK293-expressed) (rMuThpo, His) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Mouse Thrombopoietin, His (HEK293-expressed) (rMuThpo, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Thrombopoietin (TPO) is the master cytokine regulator of megakaryopoiesis. In addition to regulation of megakaryocyte and platelet number, TPO is important for maintaining proper hematopoietic stem cell (HSC) function. TPO produced mainly in the liver, stimulates both megakaryocyte colony formation and enhances megakaryocyte maturation in the bone marrow leading to increased platelet production. TPO binds to its receptor, TPOR/MPL, which is expressed on hematopoietic stem cells (HSCs), megakaryocytes and platelets. Circulating TPO concentrations are controlled by MPL via receptor-mediated internalization and degradation, and in part by sensing of senescent platelets by the Ashwell-Morell receptor in the liver[1].
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