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Recombinant Human Tumor Necrosis Factor alpha, His
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| 性状 | Recombinant Human Tumor Necrosis Factor alpha, His 是一种带有标签的人重组肿瘤坏死因子α (TNF-α)。Recombinant Human Tumor Necrosis Factor alpha 是一种多效性细胞因子，是炎症的主要介质之一，参与多种传染病和寄生虫病。似乎与血脑屏障、炎症、血栓形成和脑损伤相关的血管变化有关。
Synonyms rHuTNF-α, His; Cachectin; TNFSF2 ; 重组人肿瘤坏死因子 α，His 标签 Species Human Source E. coli Accession P01375 Gene ID 7124 Molecular Weight Approximately 18.3 kDa AA Sequence MHHHHHHVRS SSRTPSDKPV AHVVANPQAE GQLQWLNRRA NALLANGVEL RDNQLVVPSE GLYLIYSQVL FKGQGCPSTH VLLTHTISRI AVSYQTKVNL LSAIKSPCQR ETPEGAEAKP WYEPIYLGGV FQLEKGDRLS AEINRPDYLD FAESGQVYFG IIAL Biological Activity The ED50 is <0.13 ng/mL as measured by L-929 mouse fibrosarcoma cells, corresponding to a specific activity of >7.69 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <1.0 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Tumor Necrosis Factor alpha, His (rHuTNF-α, His) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Tumor Necrosis Factor alpha, His (rHuTNF-α, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 4 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine produced by a wide variety of cell types of mostly hematopoietic, but also of nonhematopoietic, origin. TNFα is instrumental in the immune elimination of various infectious agents such as Candida albicans, Listeria monocytogenes, or mycobacteria and exerts potent proinflammatory effects, e.g. by inducing the expression of adhesion molecules such as VCAM-1, intercellular adhesion molecule 1 (ICAM-1), or E-selectin on endothelial cells and other cell types. Aberrant production of TNFα, however, has been also implicated in the pathogenesis of various diseases, such as rheumatoid arthritis, insulin-dependent diabetes-mellitus, sialoadenitis, and inflammatory bowel disease, in particular Crohn's disease[1][2]. |
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