1. 首页
  2. 生化科研试剂
  3. 蛋白质组化

Recombinant Human TIGIT, Fc Chimera (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132931-10 μg 0 ￥2800 请登录
- +
1308132931-50 μg 0 ￥6400 请登录
- +
偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。
别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human TIGIT, Fc Chimera (HEK293-expressed) 是在 HEK293 细胞中产生的含有352个氨基酸的多肽链，带有C-端的人 IgG1 Fc 片段。T-cell immunoreceptor with Ig and ITIM domains (TIGIT)，也被称为 V-set 和免疫球蛋白结构域的蛋白9 (VSIG9)、V-set 和跨膜结构域的蛋白3 (VSTM3)。它属于单通道 I 型膜蛋白，包含免疫球蛋白可变结构域、跨膜结构域和免疫受体酪氨酸抑制基序 (ITIM)。
Synonyms
rHuTIGIT, Fc Chimera; VSIG9; VSTM3; T Cell Immunoreceptor with Ig and ITIM Domains ; 重组人 TIGIT，FC 嵌合体 (HEK293 细胞表达)
Species
Human

Source
HEK 293

Accession
Q495A1

Gene ID
201633

Molecular Weight
50-55 kDa

AA Sequence
MMTGTIETTG NISAEKGGSI ILQCHLSSTT AQVTQVNWEQ QDQLLAICNA DLGWHISPSF KDRVAPGPGL GLTLQSLTVN DTGEYFCIYH TYPDGTYTGR IFLEVLESSV AEHGARFQIP

Biological Activity
5 µg/mL (100 µL/well) of immoblized recombinant human CD155-Fc can bind human Biotin-TIGIT-Fc with a linear range of 6.1-48.83 ng/mL.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS, 5% trehalose and mannitol.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human TIGIT, Fc Chimera (HEK293-expressed) (rHuTIGIT, Fc Chimera) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human TIGIT, Fc Chimera (HEK293-expressed) (rHuTIGIT, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
T cell Ig and ITIM domain (TIGIT) is a transmembrane glycoprotein belonging to a poliovirus receptor family of type 1 proteins that also binds to CD155 and CD112 ligands. TIGIT is expressed on peripheral memory and regulatory CD4+ T cells and NK cells and is upregulated following activation on naive CD4+ T cells. CD155 is a high-affinity receptor for TIGIT expressed on monocytes and CD11c+ human dendritic cells (DCs). TIGIT contains an Ig-like V-type domain and an ITIM in its cytoplasmic domain, suggesting that receptor occupancy may trigger a negative signaling event[1].
贮存
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的，不可用于人类或动物的临床诊断或者治疗，非药用，非食用。
X
QQ