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Recombinant Human T Cell Immunoglobulin Mucin 3, Fc Chimera (HEK293-expressed)

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132932-10 μg 0 ￥3800
- +
1308132932-50 μg 0 ￥7800
- +
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Human T Cell Immunoglobulin Mucin 3, Fc Chimera (HEK293-expressed) 是一种属于T细胞免疫球蛋白样蛋白 (TIM) 家族的I型跨膜糖蛋白，参与调节先天免疫和适应性免疫。
Synonyms
rHuTIM-3, Fc Chimera; TIMD-3; CD366; HAVCR2
Species
Human

Source
HEK 293

Accession
Q8TDQ0

Gene ID
84868

Molecular Weight
60-65 kDa

AA Sequence
SEVEYRAEVG QNAYLPCFYT PAAPGNLVPV CWGKGACPVF ECGNVVLRTD ERDVNYWTSR YWLNGDFRKG DVSLTIENVT LADSGIYCCR IQIPGIMNDE KFNLKLVIKP AKVTPAPTRQ RDFTAAFPRM LTTRGHGPAE TQTLGSLPDI NLTQISTLAN ELRDSRLAND LRDSGATIR

Biological Activity
Binding ability is measured by functional ELISA, 500 ng/mL (100 µL/well) of immoblized recombinant human T Cell Immunoglobulin Mucin 3-Fc Chimera produces 50% optimal binding response approximately 5 ng/mL.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against PBS.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Human T Cell Immunoglobulin Mucin 3, Fc Chimera (HEK293-expressed) (rHuTIM-3, Fc Chimera) to 100 µg/mL using ddH2O or diluted with PBS.

Storage & Stability
Lyophilized recombinant Human T Cell Immunoglobulin Mucin 3, Fc Chimera (HEK293-expressed) (rHuTIM-3, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
T Cell Immunoglobulin Mucin 3 (TIM-3), also known as Hepatitis A virus cellular receptor 2 (HAVCR2), is an immunomodulatory molecule and upregulated in T cells by several cytokines. TIM-3 also influences mast cell function but its transcriptional regulation in mast cells has not been clarified. Human TIM-3 consists of a membrane distal variable immunoglobulin (IgV)-like domain involved in ligand interactions, a membrane proximal mucin domain and a transmembrane domain that is connected to an intracellular cytoplasmic tail involved in phosphotyrosine-dependent signaling[1][2][3].
贮存
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