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Btk Phospho (pY223) (BTK)
英文名：Rabbit Monoclonal Antibody
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检测信息查询
| 货号 | 规格 | 货期 | 库存 | 价格 | 会员价 | 订购 |
| 1308113380-100ul | 现货 | 0 | ￥0 | 请登录 |
| 别 名 | BTK,AGMX1, AT, ATK, BPK, IMD1, MGC126261, MGC126262, PSCTK1, XLA,Tyrosine-protein kinase BTK,Bruton tyrosine kinase |
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| 产品参数 | 【产品介绍】Btk (Bruton tyrosine kinase also known as BPK
or ATK) is a member of the TEC family of non-receptor protein tyrosine kinase which includes Bmx, Itk and TEC. Btk is composed of a pleckstrin domain, an SH3 and SH2 domain, a catalytic kinase domain and a TEC homology domain (1). Tec family protein tyrosine kinases (TFKs) play a central role in hematopoietic cellular signaling. Initial activation takes place through specific tyrosine phosphorylation situated in the activation loop. Further activation occurs within the SH3 domain via a transphosphorylation mechanism, which for Bruton's tyrosine kinase (Btk) affects tyrosine 223. (2). Similar to Etk-TNFR2 interaction, Btk interacts with Fas, a member of the TNFR family involved in apoptosis in a ligand-independent manner (3). Btk can be activated through intramolecular autophosphorylation at tyrosine 551 and that Btk autophosphorylation is required for Btk catalytic functions (4). Recommended Applications WB, IP Applications and Recommended Dilution Factors WB: 1:10,000 - 50,000 IP: 1:40 Species Reactivity * Human, Mouse, Rat *Mouse and Rat reactivity predicted based on sequence alignment only, not based on testing Products Data A. Western blot analysis on Ramos cell lysates using anti-Phospho-BTK (pY223) RabMAb (cat. #2207-1). Cells were either (A) untreated (B) treated with pervanadate. Specificity A phospho specific peptide corresponding to residues surrounding tyrosine 223 of human BTK was used as an immunogen. This antibody detects BTK phosphorylated on tyrosine 223. |
| 性状 | 【反应特异性】Human , Mouse , Rat
【克隆 ID】EP420Y 【用途】WB , IP 【抗原分子量】77 kDa |
| 贮存 | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
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