Cytokeratin 10 (KRT10)

英文名:Rabbit Monoclonal Antibody
Cas号:
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别 名 KRT10 antibody, BCIE antibody, BIE antibody, CK10 antibody, EHK antibody, K10 antibody, KPP antibody, Keratin, type I cytoskeletal 10 antibody, Keratin-10 antibody
Cas号
M D L
分子式
分子量
产品参数 【产品介绍】Cytokeratin 10 (CK10) is a heterotetramer of
two type I and two type II keratins. CK10 is
typically associated with cytokeratin 1 (CK1). CK10
is expressed in all suprabasal cell layers, and it is
part of the acidic/high molecular weight keratin
subfamily. Defects in CK10 cause
Epidermolytic hyperkeratosis (EHK), a hereditary
skin hereditary skin disorder characterized by
blistering and a marked thickening of the stratum
corneum (1). CK10 has also been linked to cause
annular epidermolytic ichthyosis (AEI), also known as
cyclic ichthyosis with epidermolytic hyperkeratosis.
CK10, along with CK14, 15, 16, and 20, can be used
to determine if a neoplasm originated from an epithelial
or non-epithelial origin, such as the determination
of metastatic malignant tumors of epithelial origin (2).


Recommended Applications

WB, IHC, ICC, IP
Applications and Recommended Dilution Factors

WB: 1:1,000 - 10,000
IHC: 1:100 - 250
ICC: 1:100 - 250
IP: 1:30
Species Reactivity *

Human

*Cross reactivity determined by western blot only.

Products Data

A. Western blot analysis on HaCat cell lysate
using anti-cytokeratin 10 RabMAb (cat. # 2210-1),
dilution 1:100,000.

B. Paraffin-embedded human skin tissue stained
with anti-CK-10 RabMAb. Note positive staining of
suprabasal layers of keratinizing stratified epithelia
(cat# 2210-1).

Specificity

A synthetic peptide corresponding to residues in the
C-term of human Cytokeratin 10 was used as immunogen.
性状 【反应特异性】Human
【克隆 ID】EP1607Y
【用途】WB , IHC , ICC , IP
【抗原分子量】60kDa
贮存 Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.
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