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Recombinant Rat Interleukin-1 alpha (CHO-expressed)
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| 性状 | Recombinant Rat Interleukin-1 alpha (CHO-expressed) 是一种非分泌的促炎细胞因子，主要由活化的巨噬细胞，中性粒细胞，上皮细胞和内皮细胞产生。
Synonyms rRtIL-1α; Hematopoietin-1; IL1A; IL1F1; IL-1 alpha Species Rat Source CHO Accession P16598 Gene ID 24493 Molecular Weight 17-22 kDa AA Sequence APHSFQNNLR YKLIRIVKQE FIMNDSLNQN IYVDMDRIHL KAASLNDLQL EVKFDMYAYS SGGDDSKYPV TLKVSNTQLF VSAQGEDKPV LLKEIPETPK LITGSETDLI FFWEKINSKN YFTSAAFPEL LIATKEQSQV HLARGLPSMI DFQIS Biological Activity The ED50 is <5 pg/mL as measured by D10S cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Rat Interleukin-1 alpha (CHO-expressed) (rRtIL-1α) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability Lyophilized recombinant Rat Interleukin-1 alpha (CHO-expressed) (rRtIL-1α) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background IL-1alpha and IL-1beta have potent effects on the central nervous system resulting in fever, activation of the hypothalamic-pituitary-adrenal axis and behavioural depression. IL-1alpha and IL-1beta show some species specificity in the potency of their biological activities, the objective of the present work was to directly compare the effects of recombinant rat IL-1alpha and IL-1beta in the rat system as a first step to dissect out the mechanisms that are involved in these effects. In vitro, recombinant rat IL-1alpha and IL-1beta bind with the same affinity as human IL-1 to the rat insulinoma Rin m5F cell line that mainly expresses type I IL-1 receptors. This binding activated IL-1 receptors, as shown by induction of the synthesis of TNF-alpha mRNA. In vivo, recombinant rat IL-1alpha and IL-1beta enhance body temperature, increase plasma levels of corticosterone and ACTH, and depress social behavior[1]. |
| 贮存 |
- Recombinant Rat Basic Fibroblast Growth Factor
- Recombinant Rat Epidermal Growth Factor
- Recombinant Rat Granulocyte-Macrophage Colony Stimulating Factor (CHO-expressed)
- Recombinant Rat Interferon-gamma
- Recombinant Rat Interleukin-1 alpha (CHO-expressed)
- Recombinant Rat Interleukin-1 beta
- Recombinant Rat Interleukin-10
- Recombinant Rat Interleukin-5
- Recombinant Rat Interleukin-6 (HEK293-expressed)
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