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Recombinant Human Growth Hormone
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性状 | Recombinant Human Growth Hormone 是一种多肽激素,可刺激生长、细胞繁殖和细胞再生,能用于治疗儿童生长障碍。
Synonyms rHuGH; Somatotropin; GH-N; GH1 ; 重组人生长激素 Species Human Source E. coli Accession P01241 Gene ID 2688 Molecular Weight Approximately 22.1 kDa AA Sequence FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F Biological Activity The ED50 is <0.5 ng/mL as measured by rat Nb2-11 lymphoma cells, corresponding to a specific activity of >2.0 × 106 units/mg. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Growth Hormone (rHuGH) to 100 μg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Growth Hormone (rHuGH) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Recombinant Human Growth Hormone is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration, which can be used for the treatment of growth disorders in children[1]. Growth Hormone is a stress hormone that stimulates production of IGF-1 and raises the concentration of glucose and free fatty acids[2]. Growth Hormone exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway[3]. |
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