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Recombinant Rat Platelet-Derived Growth Factor-BB

英文名：
Cas号：
检测信息查询
货号 规格 货期 库存 价格 会员价 订购
1308132789-10 μg 0 ￥3800 请登录
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1308132789-50 μg 0 ￥7600 请登录
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别 名
Cas号
M D L
分子式
分子量
产品参数
性状 Recombinant Rat Platelet-Derived Growth Factor-BB 属于 PDGF 家族，通过与 PDGF 受体结合，促进细胞增殖、存活和迁移。
Synonyms
rRtPDGF-BB; PDGF-2; Pdgfb ; 重组大鼠血小板衍生生长因子-BB
Species
Rat

Source
E. coli

Accession
Q05028

Gene ID
24628

Molecular Weight
Approximately 24.6 kDa

AA Sequence
MSLGSLAAAE PAVIAECKTR TEVFQISRNL IDRTNANFLV WPPCVEVQRC SGCCNNRNVQ CRASQVQMRP VQVRKIEIVR KKPVFKKATV TLEDHLACKC ETVVTPRPVT

Biological Activity
The ED50 is <2 ng/mL as measured by 3T3 cells, corresponding to a specific activity of >5.0 × 105 units/mg.

Appearance
Lyophilized powder.

Formulation
Lyophilized after extensive dialysis against 20 mM acetic acid.

Endotoxin Level
<0.2 EU/μg, determined by LAL method.

Reconstitution
Reconstitute the lyophilized recombinant Rat Platelet-Derived Growth Factor-BB (rRtPDGF-BB) to 100 μg/mL using 20 mM acetic acid.

Storage & Stability
Lyophilized recombinant Rat Platelet-Derived Growth Factor-BB (rRtPDGF-BB) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping
Room temperature in continental US; may vary elsewhere.

Background
Platelet derived growth factor (PDGF) is a potent mitogen and chemoattractant for mesenchymal and osteogenic cells and stimulates angiogenic molecules which play an essential role in bone regeneration[1]. Platelet-Derived Growth Factor-BB is a member of PDGF family, which promotes cell proliferation, survival and migration, through binding to the tyrosine kinase PDGF receptor. PDGF-BB exerts beneficial effects on haemorrhagic shock, which are closely related to targeting CX43 to improve vascular reactivity and haemodynamics. PDGF-BB functions in corporal cavernosum smooth muscle cells (CCSMCs) via binding to PDGFR[2].
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